NAD+ Activates KNa Channels in Dorsal Root Ganglion Neurons

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NAD+ activates KNa channels in dorsal root ganglion neurons.

Although sodium-activated potassium channels (KNa) have been suggested to shape various firing patterns in neurons, including action potential repolarization, their requirement for high concentrations of Na+ to gate conflicts with this view. We characterized KNa channels in adult rat dorsal root ganglion (DRG) neurons. Using immunohistochemistry, we found ubiquitous expression of the Slack KNa ...

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ژورنال

عنوان ژورنال: Journal of Neuroscience

سال: 2009

ISSN: 0270-6474,1529-2401

DOI: 10.1523/jneurosci.0859-09.2009